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Powered by accretion onto supermassive black holes (SMBH), Active Galactic Nuclei (AGN) jets represent the extreme and largest members of a wide family of jet-powered phenomena including gamma-ray bursts, X-ray binaries, young stellar objects, etc.. The beamed radiation from the jets pierces through the Universe and reaches us from billions of years in the past offering a unique opportunity to study the Universe when it was an order of magnitude younger than today. Understanding the micro- and macro-physics of jet launching and particle acceleration is one of the fundamental goals of modern astrophysics. This session focuses on how SMBHs generate ultra-relativistic jets and powerful gamma-ray emission, including various aspects of SMBH lives including accretion, launching, collimation and termination of relativistic jets, AGN feedback, high-energy acceleration and emission processes, and key advances in both theory and observations. Contributions are invited to review theoretical and observation advances, including observing strategies for future missions (SKA, JWST, IXPE, AMEGO, CTA, LISA, LSST, etc.).