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The key topic of the IU conference series is: “What is the role of information in the Universe and its description?”. In an epoch where scientists need to handle Big Data and simulations, find highly organized systems in nature and grapple with the role of information in physics and other sciences, this appears to be one of the more fundamental questions that needs to be answered in order to understand the world around us. The Information Universe conference intends to unite various approaches, addressing the fundamental role of information both in nature (in vivo) and in data analysis, theory and computer modelling (in vitro). The conference will approach the key role of information from the point of view of several disciplines: e.g. cosmology, physics, mathematics, life sciences, computer science (including quantum computing) and neuroscience.