Abstract

Significant progress has been made in characterizing the genetics of cancer and cellular pathways that are critical for cancer initiation and progression. However, most studies focused on single genes or proteins and highlighting the need to analyze cancers as integrated systems of gene/protein/metabolite networks and the underlying regulatory mechanisms. Over the past 10 years, there has been an explosion in experimental data obtained using high-throughput technologies, such as genomic sequencing, transcriptomics, metabolomics, and proteomics. Quantitative and single-cell data combined with mathematical modeling have been extensively applied to analyze cancer-related processes and cancer cell responses to drug treatments. The focus of this EMBO Workshop will be to gather some of the world’s best scientists working in the above-mentioned fields of cancer systems biology, bringing together scientists applying genome-scale or quantitative biology approaches. The program includes the following main subjects: Application of systems approaches to cancer research Quantitative and single cell cancer biology Drug discovery and cancer therapeutics New methodological developments