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We are living in an extremely interesting period in cancer research. Knowledge gained in the last decades is now entering the clinic and new findings are translated into the clinic at a pace never seen before. Most of the successes come from our understanding of basic processes that govern cancer initiation and progression, including signal transduction. Consequently, we see that especially inhibitors to signalling molecules, in particular kinases, are entering the clinic very rapidly. Therefore, the molecular mechanisms by which signals are received by cells, transduced towards the proper targets and integrated into a biological response is amongst the most-studied areas in modern biology. In this EMBO|FEBS Lecture Course we are bringing together a number of true experts in the field from basic and translational oncology. This MBO|FEBS Lecture Course will cover signalling by various pathways (PI3K, WNT, RAS/RAF) but also DNA damage and protein degradation signalling. We will also cover the consequences of pathway deregulation for cellular processes like metabolism and damage repair. Finally, the application or translation of this knowledge into the clinic will be discussed by the speakers.