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Ageing is accompanied by a continuous decline in the capacity to maintain organ homeostasis and regeneration. Driven by the increasing interest in the field of ageing and regeneration as well as recent discoveries and progress in this area of research, we consider it important to bring the field of ageing-associated organ dysfunction, stem cells and regeneration to the attention of young scientists. The latter will be brought together with leaders in the field who have contributed to breakthroughs in our understanding of ageing and regeneration using different animal models. The format of this EMBO-FEBS Lecture Course, including talks, tutorials, discussions, poster presentations and common dinners, creates a unique atmosphere and fosters interactions not only between speakers and participants, but also among the participants themselves. The following topics will be covered: Ageing models DNA damage repair and ageing Key signalling pathways in regeneration and ageing Metabolism & ageing Parallels between embryogenesis and organ regeneration Regeneration in non-vertebrates and vertebrates Senescent cells in ageing and regeneration Stem cell ageing