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Septins, GTP binding proteins that assemble into filaments, are recognized as a unique component of the cytoskeleton. Important for their roles in cytokinesis, septins have also been implicated in various cellular processes including membrane dynamics, vesicle trafficking, and host-pathogen interactions. Many new advances have greatly improved our understanding of septin function in vivo. This EMBO Workshop will concentrate on recent findings and their impact on human diseases.