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The aim of the meeting is to bring together recognized experts and outstanding young team leaders around the central theme of hematopoietic stem cells (HSCs) production and regulation throughout life. It will be essential to generate new hypotheses and to move forwards our understanding of HSCs, the key cell type for the continuous production of blood cells throughout life. Finally we wish to give the opportunity to European researchers, especially junior ones, to attend a cutting-edge conference dedicated to HSCs biology.