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ACM BCB 2015 will be held in Atlanta GA during September 9–12, 2015. The conference offers a forum for premier interdisciplinary research linking computer science, mathematics, statistics, biology, bioinformatics, biomedical informatics, and health informatics. The past few decades have seen tremendous growth in the scale and complexity of biological and medical data. This conference serves to showcase leading-edge research on new technologies and techniques for gathering, processing, analyzing, and modeling these big data for a variety of scientific, clinical, and healthcare applications, from bench to bedside.