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“BRCA: Challenges and Opportunities – the Sixth International Symposium of Hereditary Breast and Ovarian Cancer ” represents a unique opportunity to look at all aspects of breast and ovarian cancer, and in particular the susceptibility genes, BRCA1 and BRCA2, which are responsible for a considerable fraction of early-onset breast cancer. It is an accredited continuing educational activity for physicians and genetic counselors. This is THE major international conference in the world that covers specific targeted therapies for hereditary cancer. Clinicians and researchers from over 25 countries will gather for the sixth edition of this event which has come to be recognized as one of the leading international scientific conferences on hereditary breast and ovarian cancer.