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On behalf of the MRC Network of Hubs for Trials Methodology Research, I am delighted to invite you to the 3rd International Clinical Trials Methodology Conference, to be held at the Scottish Exhibition and Conference Centre (SECC) on 16 and 17 November 2015. Following on from our successful clinical trials methodology conferences in Bristol in 2011 and Edinburgh in 2013, we are preparing to welcome up to 800 delegates to Glasgow this November.