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As one of the most investigated areas in biomedical research, the cancer field is rapidly advancing by translating biological insights towards better detection and therapeutics, including molecular classifications as well as immunotherapies. In the era of the genetically informed, emerging concepts in cancer biology and oncology research are colliding into precision medicine. In order to accelerate the development of personalized cancer therapies and further translate fundamental discoveries into the clinic, there must be open lines of communication at the interface between the lab and the clinic. Our goal in organizing this Cell Symposium, Hallmarks of Cancer, is to convene global leaders in the cancer research arena to enhance our understanding of the key aspects of cancer and how to promote translation of this knowledge into the development of targeted therapeutics. We aim to provide a high-impact, high-profile forum for exchanging ideas and establishing a dialogue amongst clinicians, scientists and drug development companies. Symposium themes: Tumor metabolism, Tumor heterogeneity, Tumor immunology and immunotherapy, Personalized cancer therapy, Metastasis and the tumor microenvironment.