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Dependable Medicine using advanced Information and Communication Technology (ICT) based on Regulatory Science (RS) is the focus of the IEEE 10th International Symposium on Medical Information and Communication Technology (ISMICT 2016). ISMICT 2016 aims to establish a forum or a venue to present new research and development results, exchange ideas, discuss practices, and share experiences among Technology and Medicine sides including healthcare, wellness, clinical therapy, and surgery as well as ICT, mechanical, and biomedical engineering. Moreover, activities of standard, regulation, and business for medical ICT devices, systems and services will be promoted by local, national, and global government and industry. ISMICT 2016 will be held in Worcester Polytechnic Institute, Worcester, Massachusetts, United States between 21-23 March 2016. Worcester is a college town located in the west of Boston.