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This FASEB Science Research Conference focuses on calcium channels, signaling pathways and binding proteins in health and disease. Calcium is indispensable for normal cell function and is well studied in neuroscience and cardiovascular research, and is emerging as a highly relevant pathway in many other fields including microbiology and immunology. The conference is attended by leaders in the calcium field from around the globe. By including trainees and new investigators as speakers and poster presenters and by programming of career development workshops, the conference actively aims to nurture the next generation of scientists. Topics include: Imaging calcium signals in living tissues, Calcium in mitochondria & organelles, Store-operated calcium entry, Calcium in immunity & infection, Calcium channel structure & function, Cell physiology of calcium signals, Calcium in disease, Late-breaking topics in calcium signaling.