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This FASEB Science Research Conference will present the very latest developments in this field, with talks by leading international experts working with both prokaryotic and eukaryotic models. This unique blend from the two communities is always much appreciated by attendees of this meeting and one of its main highlights. The topics covered will include events occurring at both the 5' and 3' ends of mRNA related to decay, the links between translation, quality control and mRNA stability, and the relationship between RNA degradation and disease. Two full sessions will be devoted to mechanisms of sRNA, CRISPR RNA and miRNA regulation and how they pertain to mRNA stability.There will be a total of 9 very broad-ranging sessions over the 4 days, with 36 invited speakers at the top of their fields and two internationally renowned keynote speakers, Chris Lima and JAśrg Vogel. Speakers are encouraged to present their most recent and unpublished data. There will be two poster sessions and 2-3 additional speakers per session will be chosen to give oral presentations, based on the submitted abstracts.