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This conference will focus on the functional disulfides that contribute to regulation of thrombosis, inflammation and immunity in mammals. How protein function in these systems is regulated by disulfide bond cleavage and the factors that cleave the bonds will be discussed. The chemistry and molecular dynamics of cleavage of functional disulfides will be addressed, and the bioinformatic and experimental approaches used to identify and study these bonds will be examined. Some functional disulfides have been linked to human disease and progress is being made on ways of targeting these bonds for new diagnostics and therapies. Small molecule inhibitors of the factors that cleave functional disulfides are in pre-clinical and clinical development.