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This 4 day course is designed to introduce the participant to molecular hybridization and in situ hybridization techniques. The application of these techniques to current research questions in genetics and gene expression, molecular pathology, and pathogen detection and identification will be discussed. Probe application and detection systems will serve as the basis for both RNA and DNA in situ hybridization techniques to be addressed in lecture and laboratory. This course will be staffed by clinical and basic scientists familiar with the applications of hybridization techniques to the problems of human disease.