This workshop, sponsored by AIM and the NSF, will be devoted to topological modeling and analysis of biomolecules. A major feature of life sciences in the 21st century is their transformation from phenomenological and descriptive disciplines to quantitative and predictive ones. Revolutionary opportunities have emerged for mathematically driven advances in biological research. However, the emergence of excessive complexity in self-organizing biological systems poses fundamental challenges to their quantitative description. Dealing with the connectivity and transformation of different components in a space, topology provides a dramatic simplification of biomolecular data and sheds light on drug design, protein folding, organelle function, signaling, gene regulation networks and topology-function relationship.