As we aim to study ever more complex systems including large, flexible and frequently transient macromolecular assemblies and their function in the cellular context, the limitations to study biological structure and mechanisms become ever more apparent.A strategic goal in modern biology is to overcome some of these limitations and to bridge the divide between structural molecular biology and structural cell biology. While each technique on its own and computational methods are becoming ever more powerful, it is expected that major gains will be made by new technologies and by applying integrative or a€˜hybrida€™ approaches to the study of challenging biological systems.
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