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The second Zing conference on a€˜Genomic Integritya€™ in Dublin will build on the success of the 2015 conference held in Cairns, Australia. The meeting will focus on the molecular pathways that protect living organisms from deleterious genetic changes. It will include sessions covering both established areas in the field, including excision repair pathways, DNA damage signalling, translesion synthesis and recombination as well as more emergent topics such as DNA damage in mitosis and the role of RNA in the DNA damage response. There will also be sessions covering human disorders and therapeutic targeting of genome stability.