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Cytokine JAK-STAT pathways are intimately associated with innate and adaptive immunity, inflammation, stem cell and developmental biology, and diverse aspects of cancer biology. As JAK-STAT pathways produce both common and unique phenotypes critical for a vast range of biological phenomena, the basic understanding of how these signal transduction cascades are regulated, function and integrate with additional cellular responses has been continuously refined by discoveries of general and pathway-specific mechanisms. Furthermore, drug discovery efforts have produced small molecules targeting JAKs and STATs that are promising agents in clinical treatment of inflammation, arthritis and a variety of cancers. This meeting, coinciding with the 25th year of the discovery of JAK-STAT signaling, will couple invited speakers who have made significant contributions to allied disciplines with cytokine JAK-STAT veterans, with ample opportunities for short talks selected from submitted abstracts.