Abstract

Virtually all vital cellular processes are controlled by protein-protein interactions (PPIs) including gene expression, proliferation, intracellular communication and apoptosis. Thus, understanding and manipulating PPIs represents a key objective in being able to understand healthy and disease biology. Achieving this goal will lead to probes of cell signalling pathways or, systems biology and next generation molecular therapeutics. However, to date, only a few PPIs have been the subject of a drug discovery initiative by the pharmaceutical industry.