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Building on the success of the previous conferences, we are delighted once again to invite you to an exciting scientific program this year focusing on how to adapt international practice guidelines of multiple specialities to the local patient population. The conference explores the Global, Genetic and Geographic (G3) differences in disease incidence, prevalence Pathophysiology response to treatment and prognosis as well as the influence of internationally developed clinical practice guidelines and their relevance and impact on local practice and patient outcomes.