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The key topic of the IU conference series is: “What is the role of information in the Universe and its description?”. In an epoch where scientists need to handle Big Data and simulations, find highly organized systems in nature and grapple with the role of information in physics and other sciences, this appears to be one of the more fundamental questions that needs to be answered in order to understand the world around us. The Information Universe conference intends to unite various approaches, addressing the fundamental role of information both in nature (in vivo) and in data analysis, theory and computer modelling (in vitro). The conference will approach the key role of information from the point of view of several disciplines: e.g. cosmology, physics, mathematics, life sciences, computer science (including quantum computing) and neuroscience. The deeper role of information is formulated in different ways by these various disciplines, leading to a multitude of fundamental questions such as: - Is there a deeper physical description of space-time and gravity based on information? - The Big Data Universe and our Universe: are our numerical simulations and Big Data - - - - repositories (in vitro) different from real natural system (in vivo)? - Will quantum systems dominate the future of computing? - What is the role of information in highly organized complex life systems and genetics? - What will be the role of machine learning in the future of science? - How will big datasets from new experiments, such as Euclid, help us in understanding fundamental cosmological problems: dark matter, dark energy, inflation and structure formation? - Is the universe one big information processing machine, a hologram, one of many? The conference will be held in the new 260 seats planetarium theatre in Groningen, which provides an inspiring immersive 3D full dome display, e.g. numerical simulations of the formation of our Universe, and anything else our presenters wish to bring in. The digital planetarium setting will be used to visualize the theme with modern media.