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The Gordon Research Seminar (GRS) on Cell Polarity Signaling (June 2-3, 2018) will gather young scientists (graduate students and postdoctoral fellows) to present and discuss their latest cutting-edge findings in this exciting field of research, whilst promoting career networking and mentoring. All organisms, from bacteria to plants to humans, require highly organized internal structures to survive. Such a refined arrangement relies on Cell Polarity. This ability to respond to external cues by establishing and maintaining an asymmetric distribution of cellular components along a polarity axis is of the utmost importance for a cell to fulfill its function. Exploring a wide range of in silico, in vitro and in vivo models, this seminar will focus on the molecular mechanisms controlling single cell polarization while also concentrating on how do groups of cells coordinate their internal polarized state to provide polarity axis in tissues. Finally, how disrupted cell polarity is involved in disease initiation and progression will be discussed.