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Autophagy continues to be one of the most exciting and topical subjects in biology. Since the first Autophagy Harden Conference (the 68th Harden, held in 2010), our understanding of the basic regulatory mechanisms and the physiological roles of autophagy in health and disease has advanced substantially. Recent years have seen an impressive diversification in autophagy techniques and model systems, as well as seeing autophagy knowledge put to many novel practical applications, including disease intervention for which novel autophagy modulators are in the pipeline. This meeting brings together experts in the autophagy field from across the world to present cutting edge research on the molecular control of autophagy and the roles of autophagy in immunity, physiology and disease.