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The broad goal of this conference is to provide a platform in which to discuss emerging ideas and concepts in signal transduction. This conference represents an historical tradition of signal transduction meetings stemming from the early 1970s in the era of cyclic AMP as a second messenger. In this regard, this meeting represents one of the premier venues to learn about cutting-edge signaling mechanisms. The meeting sessions will focus on themes of regulation of signal transduction pathways and their inter-connectivity in metabolism, neuroscience, the cardiovascular system and cancer. These sessions will feature presentations that explore the molecular mechanisms, spatial integration of kinases, phosphatase and G-protein-mediated signaling in mammalian systems and model organisms. How these networks impact human disease will be a common theme throughout the conference. The goal of this meeting is to foster an exciting environment in which questions can be asked and collaborations forged. As such, the structure of the meeting is particularly well-suited for graduate students, post-docs and early-stage investigators to present their work and ample slots will be available for selected presentations from submitted abstracts.