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This FASEB SRC will bring together international scientists from different backgrounds to discuss cutting-edge developments in the areas of immunoreceptors and immunotherapy. Immunoreceptors encompass an array of receptor types, including B/T cell receptors, cytokine and immunomodulatory receptors that play a central role in cancer, autoimmunity and infectious disease. Although the field of immunoreceptors is well established, there are significant growth areas that continue to drive the field forward. An important aspect of this SRC is that it encompasses the development of state-of-the-art approaches ranging from molecular biophysics (e.g. single molecule imaging) to humanized mouse models to investigate multiple facets of immunoreceptor behavior.