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This FASEB SRC brings together leading international investigators in the field, junior scientists, and those who have recently entered the field of protein ubiquitination. Structural, molecular, and cellular biology continue to reveal both novel and common themes in protein ubiquitination. Exciting progress and new discoveries continue to expand the basic and clinical potential of understanding Ubiquitin (Ub) and Ubiquitin-like proteins (Ubls), particularly in the areas of cancer biology, infectious diseases, muscle wasting, and neurologic diseases, and are driving innovative efforts in drug discovery.