Abstract

This FASEB SRC will highlight current advances in our understanding of the pathways, mechanisms and enzymatic activities controlling RNA turnover in eukaryotic and prokaryotic cells and by viruses. Topics will cover 5’ and 3’ events in mRNA degradation, structure and function analysis of RNA decay enzymes, the coupling of mRNA translation and decay, RNA quality control mechanisms, regulatory functions of RNA-binding proteins and small non-coding RNAs, and RNA turnover in development and disease.