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ISMB brings together scientists from computer science, molecular biology, mathematics, statistics and related fields. Its principal focus is on the development and application of advanced computational methods for biological problems. ISMB 2018 provides an intense multidisciplinary forum for disseminating the latest developments in bioinformatics/computational biology, fostering fresh dialogues and perspectives to learn about and shape the future of the field. With intensified community involvement form the ISCB Communities of Special Interest (COSIs), ISMB is the leading conference in the field, with the strongest scientific and technical program that showcases the best international developments in bioinformatics and computational biology.