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The 2018 Gordon Research Seminar (GRS) on Post-Transcriptional Gene Regulation is a unique forum where early-career scientists can discuss cutting-edge data and new ideas in the field of post-transcriptional gene regulation. This meeting aims to provide an opportunity for graduate students and post-doctoral researchers to network, establish collaborations, and interact with senior investigators from the associated Gordon Research Conference (GRC). An important goal of the meeting is to create a professional setting for participants to interact with other GRS and GRC attendees from all over the globe. Meeting participants will represent academia, industry, and government, providing young investigators the chance to explore a variety of potential future careers in an approachable atmosphere. The 2018 GRS theme is "Post-Transcriptional RNA Processing: Surveys, Mechanisms and Disease." The seminar will cover RNA-related work from large-scale surveys involving genome-wide techniques, mechanistic studies in post-transcriptional regulation as well as work on post-transcriptional gene regulation in disease. Trainees working on these and other aspects of RNA-mediated gene regulation are invited to submit an abstract describing their unpublished work. Approximately 10 research talks will be chosen from abstract submissions. In addition, a poster session will enable all participants to present their research and receive valuable feedback from their peers. The overall goal of the GRS is to create a relaxed, inclusive and trainee-focused environment to facilitate the scientific and career development of seminar attendees.