Abstract

This FASEB SRC will present new discoveries in Ca2+ signaling at the basic and translational levels. Calcium is the most ubiquitous second messenger in biology and plays critical roles in a wide range of dynamic process from synaptic transmission to sensory perception, development, gene expression, cell migration, the immune response, and heart function. Defects in Ca2+ signaling lead to a correspondingly large number of serious diseases, including nervous disorders (stroke, mental illness, neurodegenerative diseases), immunodeficiencies, hypertension, cardiac arrhythmias, and developmental defects.