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The 48th Drug Metabolism Gordon Research Conference will focus on cutting edge research in drug ADME (absorption, distribution, metabolism, elimination), encompassing a wide range of research from the cellular level to the patient. Complexity in biological systems and enzymatic processes is continually uncovered in science. The conference aims to illuminate this biological complexity, often studied with simple biological and mathematical models, in order to enhance the application of new knowledge to understanding drug safety and efficacy in the clinic.