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The Computational Modeling of Biological Systems (SysMod) Community Of Special Interest aims at bridging the gap between bioinformatics and systems biology modeling. With advances in genomics these fields have recently started to converge. For example, systems modeling has become more reliant on bioinformatic network inference to build models and has begun to use transcriptomics and proteomics data to train models. More communication between systems modelers and bioinformaticians is needed to further integrate these fields. In particular, more communication between systems modellers and bioinformaticians is needed to build models of whole cells, organs and organisms. Furthermore, the promises of precision medicine lie, in part, on the interplay between bioinformatics-based analysis of patient data and model-based predictions of treatments.