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The Gordon Research Seminar on Genomic Instability seeks to bring together graduate students, post-docs and other early-stage researchers in an informal setting to present and exchange new data and cutting-edge ideas. The atmosphere of the GRS provides a friendly forum for discussion with peers and mentors and sets Gordon Research Seminars as an exclusive opportunity for young scientists. The second edition of the Genomic Instability GRS will focus on understanding how the molecular mechanisms underlying DNA replication, repair and chromosomal organization act together to preserve genome stability. The program will feature a keynote seminar by Professor Susan Gasser as well as selected scientific talks and poster presentations by students and postdocs. Further, career opportunities will be explored during a panel discussion with scientists from academia and industry.v