Investigational drugs block bone loss in mice receiving chemotherapy

Studying mice, researchers have found a driver of bone loss related to cancer treatment. Radiation and chemotherapy can halt cell division in bone, which results in a stress response called senescence. This process is independent of hormones that affect bone health, such as estrogen. Such bone loss can be stopped by treating the mice with either of two investigational drugs already being evaluated in clinical trials, according to the researchers.

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