Stressed, toxic, zombie cells seen for 1st time in Alzheimer's: Finding may apply to 20 brain diseases; drug tandem stops decline in old mice

Tau protein accumulation is common across 20 human brain diseases. Researchers have found stressed, senescent cells in Alzheimer's disease, and established a link between tau tangles and this cell stress. The scientists used a senolytic therapy to clear the senescent cells and tau tangles in Alzheimer's mice, which improved both brain function and structure.