Brain cancer potentially resists immunotherapies by trapping T cells in bone marrow

Brain cancer potentially resists immunotherapies by trapping T cells in bone marrow

www.sciencedaily.com

Researchers have found that brain tumors in mice and humans cause immune T-cells to become trapped in bone marrow. This occurs prior to cancer treatment and explains the low circulating levels of T-cells seen in some tumor patients. The effects that brain tumors have on the cell surface S1P1 protein appear to mediate the process. These findings open the door for possible adjuvant cancer treatments.

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