Garlic ingredient from the lab bench: Short total synthesis of ajoene, a biologically active component in oil extracts of garlic

Fresh garlic extracts contain a variety of healthy organosulfur compounds, among which ajoene forms a major oil-extractable ingredient. Now, chemists have synthesized ajoene from readily available components for the first time. The results show that ajoene is accessible on a large scale with very few synthetic steps. Chemical synthesis of biologically active compounds is important for their further evaluation in medicinal research.