Proteins use a lock and key system to bind to DNA: New study challenges a fundamental assumption of how proteins interact with the human genome

Scientists have traditionally thought that DNA binding proteins use patterns in the genome's code of As, Cs, Ts, and Gs to guide them to the right location, with a given protein only binding to a specific sequence of letters. In a new study, scientists discovered that proteins must rely on another clue to know where to bind: the DNA's three-dimensional shape.