chemistrypoint

Chemistry Point

2 Years ago

Optimized binding cavity: Directed evolution of a designer enzyme with an unnatural catalytic amino acid

The impressively high conversion rates of natural enzymes partly result from increasing the catalytic activity of a selected few amino acid side chains through precise positioning within the protein binding cavity. Scientists have now demonstrated that such fine-tuning is also possible for 'designer' enzymes with unnatural catalytic amino acids.

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