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Science of Life

1 Years ago
'Nanobodies' from alpacas could help bring CAR T-cell therapy to solid tumors: Unusually small antibodies, targeted to the tumor micro-environment, curb melanoma and colon cancer in mouse models

'Nanobodies' from alpacas could help bring CAR T-cell therapy to solid tumors: Unusually small antibodies, targeted to the tumor micro-environment, curb melanoma and colon cancer in mouse models

Most CAR T-cell therapies look for antigens specific to cancer cells. A new approach instead targets the environment around the tumor, using unusually small antibodies made naturally by alpacas, camels and llamas. Using this approach in mouse models, investigators successfully curbed melanoma and colon cancer - solid tumors that currently can't be treated with CAR T-cell therapy.

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