Paralyzed mice with spinal cord injury made to walk again: Small-molecule drug reactivates dormant nerve pathways; could complement regenerative strategies

Paralyzed mice with spinal cord injury made to walk again: Small-molecule drug reactivates dormant nerve pathways; could complement regenerative strategies

Most people with spinal cord injury are paralyzed from the injury site down, even when the cord isn't completely severed. Why don't the spared portions of the spinal cord keep working? Researchers now provide insight into why these nerve pathways remain quiet. They also show that a small-molecule compound, given systemically, can revive these circuits in paralyzed mice, restoring their ability to walk.

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