Genome damage from CRISPR/Cas9 gene editing higher than thought: Caution required for using CRISPR/Cas9 in potential gene therapies

Scientists have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. This has safety implications for future gene therapies using CRISPR/Cas9 as the unexpected damage could lead to dangerous changes in some cells. The study revealed that standard DNA tests miss finding this genetic damage, and that caution and specific testing will be required for any potential gene therapies.