Structure of a 'master switch' controlling cell division

Unregulated cell division is a hallmark of cancer, and one of the key proteins involved in controlling cell division is called FoxM1. Abnormal activation of FoxM1 is a common feature of cancer cells and is correlated with poor prognosis, metastasis, and resistance to chemotherapy. Now researchers have determined the structure of this protein -- a kind of 'master switch' for cell division -- in its inactive or 'off' conformation.

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