Method to select for mammalian cells with half the number of chromosomes

Since the emergence of molecular genetics, scientists have tried to isolate haploid mammalian cells. Haploid cells are a powerful genetic tool to analyse gene function. In the past decade, a number of researchers finally succeeded in developing haploid cell line cultures. However, these cell lines are unstable and have a tendency for diploidization. Now, researchers have identified chemical compounds that increase the stability of mammalian haploid cell lines.