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Tracing the footprints of a tumor: Genomic 'scars' allow cancer profiling
- May 12, 2018
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Mutations driving cancer development leave behind specific 'scars,' so-called mutational signatures, in the genome. In principle, they allow for profiling of the cancer type and its development -- but the noisy environment of a cancer genome makes correlations difficult. Using CRISPR-Cas9 technology, researchers were able to show for the first time that specific genetic alterations indeed lead to the predicted mutational signatures observed in human cancers.
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Unkown User, "Tracing the footprints of a tumor: Genomic 'scars' allow cancer profiling", MachPrinciple, May 12, 2018, https://machprinciple.com/post/Tracing-the-footprints-of-a-tumor-Genomic-scars-allow-cancer-profiling
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