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Tracing the footprints of a tumor: Genomic 'scars' allow cancer profiling

Mutations driving cancer development leave behind specific 'scars,' so-called mutational signatures, in the genome. In principle, they allow for profiling of the cancer type and its development -- but the noisy environment of a cancer genome makes correlations difficult. Using CRISPR-Cas9 technology, researchers were able to show for the first time that specific genetic alterations indeed lead to the predicted mutational signatures observed in human cancers.

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